Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-Bromo-1-(cyclopropylmethyl)-1H-pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Bromopyrazole | HCID 16375 | — |
| 반응물 | Bromomethylcyclopropane | HCID 81503 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Bromo-1-(cyclopropylmethyl)-1H-pyrazole | HCID 51072258 | 109.7% |
반응 단계
To a solution of 4-bromo-1H-pyrazole (0.1 g, 0.68 mmol) in DMF (20 ml) were added K2CO3 (0.19 g, 1.36 mmol, 2 eq.) and (bromomethyl)cyclopropane (92 mg, 0.68 mmol, 1 eq.). The mixture was stirred at RT for 4 h. The mixture was quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude product (0.15 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447091B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-a167ce228617490a96ee8259ff7c99af |
| 출처 메모 | uspto-grants-2016_09 |