Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-Methylpiperidin-4-yl methanesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 4-Piperidinol, 1-methyl- | HCID 66048 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Methylpiperidin-4-yl methanesulfonate | HCID 4190681 | 99.9% |
반응 단계
1-Methylpiperidin-4-ol (4 g, 34.7 mmol) was dissolved in CH2Cl2 (70 ml) at 0° C. followed by the addition of Et3N (10 ml, 69.4 mmol, 2 eq.) and methanesulfonyl chloride (2.7 ml, 34.7 mmol, 1 eq.). The mixture was stirred at RT for 3 h and quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the crude product (6.7 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447091B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-95d2427a2ebc434081e05472c18fdde3 |
| 출처 메모 | uspto-grants-2016_09 |