Triethylamine → 1-Methylpiperidin-4-yl methanesulfonate

HRID 64056

반응식

HRID 64056 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([OH:8])[CH2:4][CH2:3]1.CCN(CC)CC.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>C(Cl)Cl>[CH3:16][S:17]([O:8][CH:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1)(=[O:19])=[O:18]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 660484-Piperidinol, 1-methyl-

생성물 1

HCID 41906811-Methylpiperidin-4-yl methanesulfonate수율 99.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-Methylpiperidin-4-ol (4 g, 34.7 mmol) was dissolved in CH2Cl2 (70 ml) at 0° C. followed by the addition of Et3N (10 ml, 69.4 mmol, 2 eq.) and methanesulfonyl chloride (2.7 ml, 34.7 mmol, 1 eq.). The mixture was stirred at RT for 3 h and quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the crude product (6.7 g).

후처리

  1. customquenched
  2. extractionextracted as in Intermediate Example 5(a)
  3. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-95d2427a2ebc434081e05472c18fdde3
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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