Ethyl bromoacetate → Ethyl 1H-1,2,4-triazole-1-acetate
반응식
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.C([O-])([O-])=O.[K+].[K+].Br[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]>CN(C=O)C>[N:1]1([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:5]=[N:4][CH:3]=[N:2]1참가 물질
5
실험 절차
To a solution of 1H-1,2,4-triazol (2 g, 29.9 mmol, 1.0 eq) in DMF were added K2CO3 (12.3 g, 88.9 mmol, 3 eq.) and ethyl 2-bromoacetate (4.8 g, 29.9 mmol, 1 eq). The mixture was stirred at RT for 16 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to give the product in 65% yield (3 g). LC-MS (ESI): Calculated mass: 155.0; Observed mass: 156.1 [M+H]+ (rt: 0.113 min).
후처리
- customThe mixture was quenched
- extractionextracted as in Intermediate Example 5(a)
- distillationThe solvent was distilled off
- customto give the product in 65% yield (3 g)
- custom156.1 [M+H]+ (rt: 0.113 min)
출처 및 근거
- ORD 기록
- ord-509fe4691649464e92776e45b5ffda9f
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09447091B2
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