Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Pyrrolidineacetic acid, ethyl ester → Pyrrolidin-1-ylacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Pyrrolidineacetic acid, ethyl ester | HCID 210996 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | Pyrrolidin-1-ylacetic acid | HCID 414564 | 91% |
반응 단계
The solution of ethyl 2-(pyrrolidin-1-yl)acetate (2 g, 12.7 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 91% yield (1.5 g). LC-MS (ESI): Calculated mass: 129.1; Observed mass 130.1 [M+H+] (rt: 0.26 min).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447091B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-4fed8b6380b94254a92f74f824b0f9b3 |
| 출처 메모 | uspto-grants-2016_09 |