Methanol → Candesartan Cilexetil

HRID 640735

반응식

HRID 640735 반응식
[CH3:1][CH2:2][O:3][C:4]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[C:25]([C:26]4[N:30](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[N:29]=[N:28][N:27]=4)=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[C:50]([O:52][CH:53]([O:55][C:56]([O:58][CH:59]2[CH2:64][CH2:63][CH2:62][CH2:61][CH2:60]2)=[O:57])[CH3:54])=[O:51])[N:5]=1.C1(C)C=CC=CC=1.CO>O>[CH3:1][CH2:2][O:3][C:4]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:25]=3[C:26]3[N:27]=[N:28][NH:29][N:30]=3)=[CH:16][CH:15]=2)[C:11]2[C:10]([C:50]([O:52][CH:53]([O:55][C:56]([O:58][CH:59]3[CH2:60][CH2:61][CH2:62][CH2:63][CH2:64]3)=[O:57])[CH3:54])=[O:51])=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 1140TolueneHCID 11029254Trityl candesartan cilexetil

생성물 1

HCID 2540Candesartan Cilexetil

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of trityl candesartan cilexetil (TCS, 350 g, 410.3 mmol), toluene (1050 ml), methanol (2100 ml), and water (17.5 ml) was refluxed for about 3 h (HPLC control). The solvents were evaporated at 45° C. at 90 mbar to give a residue as a viscous oil, the residue was dissolved at 50° C. in a mixture of toluene/methanol (1041 g, 95:5 w/w) to give 1391 g of a clear solution.

후처리

  1. customThe solvents were evaporated at 45° C. at 90 mbar

출처 및 근거

ORD 기록
ord-e46534512490416e960e0d4d5b7c33f9
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07692023B2

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