Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Candesartan Cilexetil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Trityl candesartan cilexetil | HCID 11029254 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Candesartan Cilexetil | HCID 2540 | — |
반응 단계
A solution of trityl candesartan cilexetil (TCC, 30.0 g, 35.17 mmol), toluene (180 mL), methanol (180 mL), and water (1.6 mL) was refluxed for about 13 h (HPLC control), and the solvents were evaporated at 60° C./30 mbar to give a residue as a viscous oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07692023B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-a0669659e51b498c8ed182bccc7d11ee |
| 출처 메모 | uspto-grants-2010_04 |