Potassium Carbonate → HCID 79362010, 화합물

HRID 64079노트

반응식

HRID 64079 반응식
[Br:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:14][CH2:15][C:16]([CH3:19])([OH:18])[CH3:17]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:14][CH2:15][C:16]([CH3:19])([OH:18])[CH3:17])[CH:6]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 163754-BromopyrazoleHCID 106071724-Bromo-2-methylbutan-2-ol

생성물 1

HCID 79362010HCID 79362010, 화합물수율 60%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-bromo-1H-pyrazole (1 g, 6.84 mmol, 1.0 eq) in DMF were added K2CO3 (2.3 g, 17.1 mmol, 2.5 eq.) and 4-bromo-2-methylbutan-2-ol (1.7 g, 10.27 mmol, 1.5 eq.). The mixture was stirred at RT for 16 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 60% yield (0.9 g). LC-MS (ESI): Calculated mass 233.0; Observed mass 235.0. [M+H]+ (rt: 0.64 min).

후처리

  1. customThe mixture was quenched
  2. extractionextracted as in Intermediate Example 5(a)
  3. distillationThe solvent was distilled off
  4. customto afford the product in 60% yield (0.9 g)
  5. custom[M+H]+ (rt: 0.64 min)

출처 및 근거

ORD 기록
ord-5ef8ce30534a4941887a18ee3f3b4646
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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