1,1'-Carbonyldiimidazole → HCID 135412678, 화합물

HRID 640804노트

반응식

HRID 640804 반응식
[NH2:1][C:2]1[C:10]([OH:11])=[C:9]([Cl:12])[CH:8]=[C:7]([Cl:13])[C:3]=1[C:4]([NH2:6])=[O:5].[CH:14]1N=CN(C(N2C=NC=C2)=O)C=1>C(O)=O>[Cl:13][C:7]1[CH:8]=[C:9]([Cl:12])[C:10]([OH:11])=[C:2]2[C:3]=1[C:4](=[O:5])[NH:6][CH:14]=[N:1]2

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 59256609HCID 59256609, 화합물

생성물 1

HCID 135412678HCID 135412678, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

According to the procedure described in Step C, 2-amino-4,6-dichloro-3-hydroxybenzamide and formic acid in the presence of CDI gave, after washing the crude product with MeOH, 5,7-dichloro-8-hydroxy-3H-quinazolin-4-one as a white solid (36%).—1H NMR (DMSO-d6): δ 8.12 (s, 1H), 7.55 (s, 1H); mass spectrum: m/z 229, 231, 233 (M+−1, 100%, 66%, 11%).

후처리

  1. customgave
  2. washafter washing the crude product with MeOH, 5,7-dichloro-8-hydroxy-3H-quinazolin-4-one as a white solid (36%)

출처 및 근거

ORD 기록
ord-b1842d6a6e1a4c17a3a999aeac1f34e8
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07692011B2

반응 노트

불러오는 중…