Benzenamine, 4-(4-morpholinyl)- → HCID 178474156, 화합물

HRID 640823노트

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HRID 640823 반응식
O[CH:2]=[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([C:14]3[CH:15]=[C:16]([NH:20][C:21](=[O:23])[CH3:22])[CH:17]=[CH:18][CH:19]=3)=[O:13])[CH:10]=2)[NH:5][C:4]1=[O:24].[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)=[CH:28][CH:27]=1>C1COCC1>[N:32]1([C:29]2[CH:28]=[CH:27][C:26]([NH:25][CH:2]=[C:3]3[C:11]4[C:6](=[CH:7][CH:8]=[C:9]([C:12]([C:14]5[CH:15]=[C:16]([NH:20][C:21](=[O:23])[CH3:22])[CH:17]=[CH:18][CH:19]=5)=[O:13])[CH:10]=4)[NH:5][C:4]3=[O:24])=[CH:31][CH:30]=2)[CH2:33][CH2:34][O:35][CH2:36][CH2:37]1

참가 물질

4

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HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 178474157N-[3-[3-(hydroxymethylidene)-2-oxo-1H-indole-5-carbonyl]phenyl]acetamide

생성물 1

HCID 178474156HCID 178474156, 화합물수율 69%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
65 °C

실험 절차

A small screw cap test tube was charged with N-[3-(3-Hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-acetamide (prepared below, 52 mg, 0.161 mmol) and THF (2 mL). To the resulting solution was added N-(4-aminophenyl)morpholine (43 mg, 0.242 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. Hexanes were added to the reaction mixture. The solid precipitate that formed was washed with ˜1 mL of i-prOH yielding 69% (54 mg, 0.111 mmol) of the title compound.

후처리

  1. customA small screw cap test tube
  2. temperatureSubsequently, the reaction mixture was cooled to room temperature
  3. customThe solid precipitate that formed

출처 및 근거

ORD 기록
ord-a8ce71d9dca742cba7ba051f0de61f8d
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07692005B2

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