Sodium Hydroxide → 5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-amine

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Hydroxide	HCID 14798	—
반응물	N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)acetamide	HCID 71554232	—
용매	Ethanol	HCID 702	—
생성물	5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-amine	HCID 117777662	77%

반응 조건

온도	85 °C

반응 단계

To a solution of the compound of Example 20 (450 mg, 0.9 mmol) in ethanol (10 ml) was added aqueous solution of NaOH (450 mg, 11.25 mmol, 12.5 eq.) and the mixture was heated at 85° C. for 2 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford the product in 77% yield (0.32 g).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09447091B2
출처 데이터셋	uspto-grants-2016_09
ORD ID	ord-c3086a9091d54629acca513578b8af88
출처 메모	uspto-grants-2016_09