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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 64097생성일: 2026년 10월 23일

Cyclopropanesulfonyl chloride → N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)cyclopropanesulfonamide

https://huagongshe.com/ko/reaction/64097

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참여 물질

역할이름HCID투입량
반응물Cyclopropanesulfonyl chlorideHCID 2760919—
반응물N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)acetamideHCID 71554232—
생성물N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)cyclopropanesulfonamideHCID 117777726—

반응 단계

The compound was prepared from the compound of Example 20 using the procedures of Example 39 and cyclopropane sulfonyl chloride. 1H NMR (400 MHz, CD3OD): δ 8.93 (s, 1H), 8.53 (s, 1H), 8.32 (s, 1H), 7.80 (d, 1H), 7.82 (d, 1H), 7.68-7.58 (m, 4H), 7.17-7.10 (m, 2H), 4.95 (t, 2H), 3.85 (t, 2H), 3.02 (s, 6H), 2.78-2.71 (m, 1H), 1.16-1.09 (m, 2H), 1.05-1.01 (m, 2H); LC-MS (ESI): Calculated mass: 563.62; Observed mass: 564.2 [M+H]+ (rt: 0.412 min).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09447091B2
출처 데이터셋uspto-grants-2016_09
ORD IDord-273bb1d92deb441282e849a3ebb06018
출처 메모uspto-grants-2016_09