Ethyl Acetate → HCID 86608383, 화합물

HRID 641177노트

반응식

HRID 641177 반응식
[NH:1]([C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[N:6]=[C:5]([O:15][CH2:16][C:17]([CH3:20])([OH:19])[CH3:18])[CH:4]=1)[NH2:2].[N:21]([O-])=O.[Na+].C(OCC)(=O)C>C(O)(=O)C.O>[N:1]([C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[N:6]=[C:5]([O:15][CH2:16][C:17]([CH3:20])([OH:19])[CH3:18])[CH:4]=1)=[N+:2]=[N-:21]

참가 물질

6

반응물 3

HCID 8857Ethyl AcetateHCID 23668193Sodium NitriteHCID 68514795HCID 68514795, 화합물

생성물 1

HCID 86608383HCID 86608383, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

1-(6-hydrazino-2-morpholin-4-yl-pyrimidin-4-yloxy)-2-methyl-propan-2-ol was dissolved in glacial acetic acid (30 mL). To this solution was added a solution of sodium nitrite (700 mg) in water (4 mL). The reaction was stirred for ten minutes, and poured into ethyl acetate (100 mL). The organic layer was then washed with water (100 mL) and 10% sodium carbonate (2×100 mL). The organic layer was dried over magnesium sulfate and evaporated to give 1-(6-Azido-2-morpholin-4-yl-pyrimidin-4-yloxy)-2-methyl-propan-2-ol, which was used without purification in the next reaction.

후처리

  1. washThe organic layer was then washed with water (100 mL) and 10% sodium carbonate (2×100 mL)
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-f52c0ab15ece449fbd7058fc9f90a701
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696202B2

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