Ammonium Chloride → N-(5-aminobiphenyl-3-yl)acetamide

HRID 64131노트

반응식

HRID 64131 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([NH:16][C:17](=[O:19])[CH3:18])[CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:9]=1)([O-])=O.[Cl-].[NH4+]>C1COCC1.O.[Zn]>[NH2:1][C:4]1[CH:5]=[C:6]([NH:16][C:17](=[O:19])[CH3:18])[CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:9]=1

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 89500237N-(5-nitrobiphenyl-3-yl)acetamide

생성물 1

HCID 308689N-(5-aminobiphenyl-3-yl)acetamide수율 94%

시약·촉매·용매 3

HCID 23994Zinc촉매HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
45 °C

실험 절차

To a solution of N-(5-nitrobiphenyl-3-yl)acetamide (1.2 g, 4.68 mmol) in THF (10 ml) were added a solution of ammonium chloride (2 g, 37.4 mmol, 8 eq.) in water (2 ml) and zinc (2.36 g, 37.4 mmol, 8 eq.). The mixture was stirred at 45° C. for 2 h and filtered. The filtrate was diluted with water and extracted as in Example 1(d). The solvent was distilled off to afford the product in 94% yield (1 g).

후처리

  1. filtrationfiltered
  2. additionThe filtrate was diluted with water
  3. extractionextracted as in Example 1(d)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 94% yield (1 g)

출처 및 근거

ORD 기록
ord-acba007b2aea44e299dfd5be3b4dfb87
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

반응 노트

불러오는 중…