Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylcarbodiimide → 4-chloro-2-(4-nitrophenylamino)-3H-imidazo-[4,5-c]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylcarbodiimide | HCID 12734 | — |
| 반응물 | Benzene, 1-isothiocyanato-4-nitro- | HCID 75044 | — |
| 반응물 | 2-Chloropyridine-3,4-diamine | HCID 285736 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-chloro-2-(4-nitrophenylamino)-3H-imidazo-[4,5-c]pyridine | HCID 178526682 | 82.9% |
반응 단계
3.1 A solution of 0.72 g of 3,4-diamino-2-chloropyridine, 0.9 g of 4-nitrophenyl isothiocyanate and 0.78 ml of N,N-diisopropylcarbodiimide in 30 ml of DMF is stirred at room temperature for 16 hours, then at 500 for 6 hours. The solvent is separated off, and the residue is crystallised from methanol, giving 1.2 g of 4-chloro-2-(4-nitrophenylamino)-3H-imidazo-[4,5-c]pyridine (“6”).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07696224B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-5af5aee4d7de41bbb82aa03f3bc06196 |
| 출처 메모 | uspto-grants-2010_04 |