Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 2,5-Dimethyl-1-phenylpyrrole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | 2,5-Hexanedione | HCID 8035 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 2,5-Dimethyl-1-phenylpyrrole | HCID 66518 | 75% |
반응 단계
A 25 mL round-bottom flask was charged with aniline (1 mL, 8.77 mmol), hexane-2,5-dione (4 mL, 43.86 mmol) and AcOH (5 mL). The reaction mixture was refluxed for 4 hrs. The mixture was diluted with HCl (10%) and extracted with EtOAc. The organic layer was dried over Na2SO4 and the solvent was removed under reduced pressure to give 190 mg of compound 4 (75%). MS [M++1]=172, LC-MS: tR=2.54 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07696227B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-efd34f39eea241b58726aa926f4bc18c |
| 출처 메모 | uspto-grants-2010_04 |