Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bicarbonate Ion → (2-Amino-4-hydroxy-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bicarbonate Ion | HCID 769 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Sodium ethanethiolate | HCID 4459711 | — |
| 반응물 | (2-Amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone | HCID 59259172 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (2-Amino-4-hydroxy-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone | HCID 59259050 | — |
반응 단계
A mixture of 1.34 g (4.48 mmol) (2-amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone, 1.88 g sodium ethanethiolate and 10 ml DMF are heated for 5 h to 110° C. Saturated aqueous bicarbonate solution (10 ml) and 100 ml water are added. The product is extracted with CH2Cl2 and chromatographed on silica (hexane/ethyl acetate).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07696216B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-baacbbfedac543bbaf0eaa3281d3a3b3 |
| 출처 메모 | uspto-grants-2010_04 |