참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Iodoisatin | HCID 88695 | — |
| 반응물 | Benzoic acid, 4-(1,1-dimethylethyl)-, hydrazide | HCID 123513 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-tert-butyl-N'-(5-iodo-2-oxoindol-3-yl)benzohydrazide | HCID 178440973 | 75% |
반응 단계
Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-tert-butylbenzohydrazide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 168 mg of the title compound (75%) as a yellow solid in 99.8% purity by HPLC (Rt: 6.65, gradient of 10 min, MaxPlot detection between 230 and 400 nm).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07696231B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_04 |
|---|
| ORD ID | ord-fdbfdf3024b4465e97cbdea545049adb |
|---|
| 출처 메모 | uspto-grants-2010_04 |
|---|
