Benzyl 4-(2-hydrazino-2-oxoethoxy)benzoate → 4-(2-Hydrazino-2-oxoethoxy)benzoic acid
반응식
[NH:1]([C:3](=[O:22])[CH2:4][O:5][C:6]1[CH:21]=[CH:20][C:9]([C:10]([O:12]CC2C=CC=CC=2)=[O:11])=[CH:8][CH:7]=1)[NH2:2]>CC(O)=O.[Pd]>[NH:1]([C:3](=[O:22])[CH2:4][O:5][C:6]1[CH:21]=[CH:20][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1)[NH2:2]참가 물질
4
실험 절차
In an Parr autoclave, a solution of benzyl 4-(2-hydrazino-2-oxoethoxy)benzoate (400 mg, 1.3 mmol) and a catalytic amount Pd/C in AcOH (25 mL) was stirred under hydrogen pressure (5 Bars) at rt for 45 min. After filtration over celite, the filtrate was evaporated off. The residue was taken up in MeOH and a beige solid precipitated out. Filtration and drying under vacuo at 50° C. overnight gave the title compound as a beige solid (118 mg) in a 42% yield.
후처리
- filtrationAfter filtration over celite
- customthe filtrate was evaporated off
- customa beige solid precipitated out
- filtrationFiltration
- customdrying under vacuo at 50° C. overnight
출처 및 근거
- ORD 기록
- ord-7eff46c438b449c48828ec83b8c1e2f2
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07696231B2
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