Benzyl 4-(2-hydrazino-2-oxoethoxy)benzoate → 4-(2-Hydrazino-2-oxoethoxy)benzoic acid

HRID 642081

반응식

HRID 642081 반응식
[NH:1]([C:3](=[O:22])[CH2:4][O:5][C:6]1[CH:21]=[CH:20][C:9]([C:10]([O:12]CC2C=CC=CC=2)=[O:11])=[CH:8][CH:7]=1)[NH2:2]>CC(O)=O.[Pd]>[NH:1]([C:3](=[O:22])[CH2:4][O:5][C:6]1[CH:21]=[CH:20][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1)[NH2:2]

참가 물질

4

반응물 1

HCID 9922354Benzyl 4-(2-hydrazino-2-oxoethoxy)benzoate

생성물 1

HCID 98558384-(2-Hydrazino-2-oxoethoxy)benzoic acid수율 43.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

In an Parr autoclave, a solution of benzyl 4-(2-hydrazino-2-oxoethoxy)benzoate (400 mg, 1.3 mmol) and a catalytic amount Pd/C in AcOH (25 mL) was stirred under hydrogen pressure (5 Bars) at rt for 45 min. After filtration over celite, the filtrate was evaporated off. The residue was taken up in MeOH and a beige solid precipitated out. Filtration and drying under vacuo at 50° C. overnight gave the title compound as a beige solid (118 mg) in a 42% yield.

후처리

  1. filtrationAfter filtration over celite
  2. customthe filtrate was evaporated off
  3. customa beige solid precipitated out
  4. filtrationFiltration
  5. customdrying under vacuo at 50° C. overnight

출처 및 근거

ORD 기록
ord-7eff46c438b449c48828ec83b8c1e2f2
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696231B2

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