참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Iodoisatin | HCID 88695 | — |
| 반응물 | 4-chloro-N-[4-(hydrazinocarbonyl)benzyl]benzamide | HCID 9857609 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | HCID 178517195 | HCID 178517195 | 92% |
반응 단계
Into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-chloro-N-[4-(hydrazinocarbonyl)benzyl]benzamide. After stirring at 100° C. the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 126 mg of the title compound (92%) as a yellow solid in 89.18% purity by HPLC (Rt: 4.48, gradient of 8 min, MaxPlot detection between 230 and 400 nm).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07696231B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_04 |
|---|
| ORD ID | ord-984a165714b744baa9099d48ba381e83 |
|---|
| 출처 메모 | uspto-grants-2010_04 |
|---|
