5-Iodoisatin → HCID 178517200, 화합물

HRID 642113노트

반응식

HRID 642113 반응식
[I:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O.[NH:13]([C:15]([C:17]1[CH:34]=[CH:33][C:20]([C:21]([NH:23][C:24]2[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=2)=[O:22])=[CH:19][CH:18]=1)=[O:16])[NH2:14]>C(O)(=O)C>[I:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[N:14][NH:13][C:15]([C:17]1[CH:34]=[CH:33][C:20]([C:21]([NH:23][C:24]2[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=2)=[O:22])=[CH:19][CH:18]=1)=[O:16]

참가 물질

4

반응물 2

HCID 886955-IodoisatinHCID 98574564-{[4-(Hydrazinocarbonyl)benzoyl]amino}benzoic acid

생성물 1

HCID 178517200HCID 178517200, 화합물수율 75%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

Into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-{[4-(hydrazinocarbonyl)benzoyl]amino}benzoic acid. After stirring at 100° C. the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 126 mg of the title compound (75%) as a orange solid in 83.3% purity by HPLC (Rt: 3.78, gradient of 8 min. MaxPlot detection between 230 and 400 nm).

후처리

  1. temperaturewas cooled to rt
  2. customa yellow solid precipitated out
  3. filtrationFiltration on a fritté
  4. washwashing with AcOH, water
  5. customdrying under vacuo at 60° C. overnight

출처 및 근거

ORD 기록
ord-9ab34eee3137434ca9749c736da1523b
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696231B2

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