6-Chloromethyl-2-methylpyridinium chloride → 2-Fluoro-4-(6-methyl-pyridin-2-ylmethoxy)-benzoic Acid Methyl Ester

반응식

[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:5]=1[F:11].Cl.Cl[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=2)=[CH:6][C:5]=1[F:11]

참가 물질

반응물 2

HCID 765456-Chloromethyl-2-methylpyridinium chloride

HCID 22463192Methyl 2-fluoro-4-hydroxybenzoate

생성물 1

HCID 576851082-Fluoro-4-(6-methyl-pyridin-2-ylmethoxy)-benzoic Acid Methyl Ester

실험 절차

The title compound is prepared in a manner substantially analogous to Procedure E except KI (1.3 eq.) is also added from 2-Fluoro-4-hydroxy-benzoic acid methyl ester [197507-22-5] and 2-(chloromethyl)-6-methyl-pyridine hydrochloride [CAS 3099-29-4]. MS (ES+) 276.2

출처 및 근거

ORD 기록: ord-776597e184134a44ac87421a55009e6d
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07696234B2

반응 노트

불러오는 중…