HCID 68577377, 화합물 → HCID 11516828, 화합물

반응식

[Li+].[F:2][C:3]1[CH:11]=[C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH:9]=[CH:8][C:4]=1[C:5]([O-:7])=O.Cl.Cl.[CH3:22][C@@H:23]1[CH2:27][CH2:26][CH2:25][N:24]1[CH2:28][C@@H:29]1[CH2:33][CH2:32][CH2:31][NH:30]1>>[F:2][C:3]1[CH:11]=[C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH:9]=[CH:8][C:4]=1[C:5]([N:30]1[CH2:31][CH2:32][CH2:33][C@H:29]1[CH2:28][N:24]1[CH2:25][CH2:26][CH2:27][C@H:23]1[CH3:22])=[O:7]

참가 물질

반응물 2

HCID 68577377HCID 68577377, 화합물

HCID 68579117(2R)-2-Methyl-1-{[(2S)-pyrrolidin-2-yl]methyl}pyrrolidine--hydrogen chloride (1/2)

생성물 1

HCID 11516828HCID 11516828, 화합물

실험 절차

The title compound is prepared in a manner substantially analogous to Procedure A from 2-Fluoro-4-(pyridin-2-ylmethoxy)-benzoic acid lithium salt and 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine dihydrochloride salt. MS (ES+) 398.3

출처 및 근거

ORD 기록: ord-e170857f5a624f8c9c81571902a1ca15
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07696234B2

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