2-Pyridin-4-yl-benzooxazol-5-ylamine → N-(2-(pyridin-4-yl)benzo[d]oxazol-5-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

HRID 64235

반응식

HRID 64235 반응식
[O:1]1[CH:6]([C:7]([OH:9])=O)[CH2:5][O:4][C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]1=2.[NH2:14][C:15]1[CH:16]=[CH:17][C:18]2[O:22][C:21]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)=[N:20][C:19]=2[CH:29]=1>>[N:26]1[CH:25]=[CH:24][C:23]([C:21]2[O:22][C:18]3[CH:17]=[CH:16][C:15]([NH:14][C:7]([CH:6]4[O:1][C:2]5[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=5[O:4][CH2:5]4)=[O:9])=[CH:29][C:19]=3[N:20]=2)=[CH:28][CH:27]=1

참가 물질

3

반응물 2

HCID 7360092-Pyridin-4-yl-benzooxazol-5-ylamineHCID 27354501,4-Benzodioxane-2-carboxylic acid

생성물 1

HCID 118254674N-(2-(pyridin-4-yl)benzo[d]oxazol-5-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

실험 절차

The general procedure for compound 8 was followed using starting materials 2,3-dihydrobenzo [b][1,4]dioxine-2-carboxylic acid and compound 4 (5-thiazole) to give title compound Q20 (73%) as a white solid. 1H NMR (CDCl3, 400 MHz) δ 4.31 (dd, J, =11.6 Hz, J2=7.2 Hz, 1H), 4.66 (dd, J1=12 Hz, J2=2.8 Hz, 1H), 4.86 (dd, J, =7.4 Hz, J2=2.8 Hz, 1H), 6.93-6.96 (m, 3H), 7.06-7.08 (m, 1H), 7.59 (s, 2H), 8.07-8.08 (m, 2H), 8.14 (s, 1H), 8.43 (s, 1H), 8.83 (d, J=5.6 Hz, 2H); 13C NMR (CDCl3, 100 MHz) δ 65.5, 73.5, 111.2, 112.6, 117.3, 118.0, 119.6, 121.2, 122.3, 123.0, 134.2, 134.3, 141.5, 142.4, 143.4, 148.2, 150.9, 161.9, 165.4; ESI-HRMS for C21H16N3O4(M+H)+ calcd. 374.1141. found 374.1138.

출처 및 근거

ORD 기록
ord-2951d4333e58460e9bd00c7c1578eebe
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447134B2

연결된 노트

불러오는 중…