2-Pyridin-4-yl-benzooxazol-5-ylamine → HCID 71662590, 화합물

HRID 64236

반응식

HRID 64236 반응식
[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:3]=1O[C@@H](C)C(O)=O.[NH2:15][C:16]1[CH:17]=[CH:18][C:19]2[O:23][C:22]([C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)=[N:21][C:20]=2[CH:30]=1>>[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:3]=1[NH:21][CH:20]([CH3:30])[C:19]([NH:15][C:16]1[CH:17]=[CH:18][C:19]2[O:23][C:22]([C:24]3[CH:25]=[CH:26][N:27]=[CH:28][CH:29]=3)=[N:21][C:20]=2[CH:30]=1)=[O:23]

참가 물질

3

반응물 2

HCID 7360092-Pyridin-4-yl-benzooxazol-5-ylamineHCID 40478653(S)-2-(2,3-dichlorophenoxy)propanoic acid

생성물 1

HCID 71662590HCID 71662590, 화합물

실험 절차

Similarly prepared as per compound 8 procedure, using (S)-2-(2,3-dichlorophenyl) propanoic acid 7 and compound 4 (4-pyridine) to obtained title compound Q60 as white solid (71%). 1H NMR (CDCl3, 400 MHz) δ 1.72 (d, J=6.8 Hz, 3H), 3.95 (dq, J=7.2 Hz, J=3.2 Hz, 1H), 4.79 (d, J=2.8 Hz, 1H), 6.56 (d, J=8.4 Hz, 1H), 6.96 (d, J=8 Hz, 1H), 7.09 (t, J=8 Hz, 1H), 7.46 (dd, J=9.2 Hz, J2=2 Hz, 1H), 7.54 (d, J=8.4 Hz, 1H), 8.06 (d, J=4 Hz, 2H), 8.09 (d, J=1.6 Hz, 1H), 8.56 (s, 1H), 8.8 (bs, 2H); 13C NMR (CDCl3, 100 MHz) δ 20.0, 56.4, 110.8, 111.1, 112.4, 118.6, 119.6, 120.9, 121.2, 128.4, 133.5, 134.3, 134.7, 142.4, 144.1, 148.0, 150.9, 161.7, 171.7; C21H17N4O2Cl2 (M+H)+ calcd. 427.0729 found 427.0724.

출처 및 근거

ORD 기록
ord-7dd4d6a1df8f41469f68ea271b29a936
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447134B2

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