1-(Bromomethyl)naphthalene → 6-Bromo-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid

반응식

C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([Br:15])[CH:9]=2)=[O:5])C.Br[CH2:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][CH:19]=1>>[Br:15][C:10]1[CH:9]=[C:8]2[C:13]([CH:14]=[C:6]([C:4]([OH:3])=[O:5])[N:7]2[CH2:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=[CH:20][CH:19]=2)=[CH:12][CH:11]=1

참가 물질

반응물 2

HCID 1378441-(Bromomethyl)naphthalene

HCID 70094966-Bromo-1H-indole-2-carboxylic acid ethyl ester

생성물 1

HCID 589002216-Bromo-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid

실험 절차

Using general procedure B, 6-bromo-1H-indole-2-carboxylic acid ethyl ester was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as white solid. MS: 380.1 ([M−H]−).

후처리

customthe product obtained

출처 및 근거

ORD 기록: ord-8f997ceb21de4a05aab43b64a5ddf91c
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07696240B2

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