Ethyl indole-2-carboxylate → 1-Benzofuran-3-ylmethyl-1H-indole-2-carboxylic acid

반응식

C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])C.Br[CH2:16][C:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[O:19][CH:18]=1>>[O:19]1[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:17]([CH2:16][N:7]2[C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:14]=[C:6]2[C:4]([OH:3])=[O:5])=[CH:18]1

참가 물질

반응물 2

HCID 73125Ethyl indole-2-carboxylate

HCID 123374973-(Bromomethyl)-1-benzofuran

생성물 1

HCID 589002531-Benzofuran-3-ylmethyl-1H-indole-2-carboxylic acid

실험 절차

Using general procedure B, 1H-indole-2-carboxylic acid ethyl ester was coupled with 3-bromomethyl-benzofuran (Lit. 19) and the product obtained was hydrolyzed to give the title compound as a white solid. MS: 290.2 ([M−H]−).

후처리

customthe product obtained

출처 및 근거

ORD 기록: ord-947feb824466429bbd46cde81b879ea7
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07696240B2

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