Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate → 4-(7-fluoro-naphthalen-1-ylmethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate | HCID 4058811 | — |
| 반응물 | 1-(Bromomethyl)-7-fluoronaphthalene | HCID 15657420 | — |
| 생성물 | 4-(7-fluoro-naphthalen-1-ylmethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid methyl ester | HCID 68578060 | — |
반응 단계
Using general procedure B, methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate was coupled with 1-bromomethyl-7-fluoro-naphthalene (from Example 49.3.) to give 4-(7-fluoro-naphthalen-1-ylmethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid methyl ester which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give the title compound as a white solid. MS: 324.4 ([M−H]−).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07696240B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-f5a6edba9be044e4935aa764bae66243 |
| 출처 메모 | uspto-grants-2010_04 |