Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → 1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Ondansetron | HCID 4595 | — |
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one | HCID 598875 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one | HCID 11790505 | — |
반응 단계
Kim et al. (Heterocycles 1997, 45, 2041) disclose a two-step synthesis of ondansetron. In the first step of the synthesis, 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one (compound of formula 1, Scheme 1) is reacted with a source of formaldehyde and morpholine in boiling glacial acetic acid to provide 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one (compound of formula 2, Scheme 1). In the second step of the synthesis, 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one is reacted with 2-methylimidazole in the presence of alumina (Al2O3) to provide ondansetron (See, Scheme 1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07696356B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-ab14a4ed59114cde9f6a7f164b3efe91 |
| 출처 메모 | uspto-grants-2010_04 |