Water → 4-Azidomethyl 1-(4-iodophenyl)imidazole
반응식
Cl[CH2:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:13]=[CH:12][C:11]([I:14])=[CH:10][CH:9]=2)[CH:7]=1.[N-:15]=[N+:16]=[N-:17].[Na+].O.CCOC(C)=O>CN(C=O)C>[N:15]([CH2:2][C:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:13]=[CH:12][C:11]([I:14])=[CH:10][CH:9]=2)[CH:7]=1)=[N+:16]=[N-:17]참가 물질
6
실험 절차
The compound 4-(chloromethyl)-1-(4-iodophenyl)-1H-imidazole 9.5 (0.780 g, 2.45 mmol) was dissolved in DMF (10 mL). To the solution, NaN3 (0.520 g, 8.00 mmol) was added. After being stirred at room temperature overnight, water and EtOAc were added. The organic layer was separated, dried over Na2SO4, concentrated in vacuo to give 4-(azidomethyl)-1-(4-iodophenyl)-1H-imidazole 9.6 as a solid (0.725 g). MS 326.0 (M+H).
후처리
- customThe organic layer was separated
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-0c6c826637bc45d0ac56a9339b91371a
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07696352B2
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