Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole → (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole | HCID 86614009 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine | HCID 65805535 | 84.1% |
반응 단계
A mixture of 3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole (100 mg, 0.31 mmol) and Ra—Ni (50% aq. slurry, 150 mg) in MeOH (8 mL) was hydrogenated under balloon H2 for 3 hrs. It was filtered through celite. The filtrate was concentrated in vacuo to give (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine (78 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07696352B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-a56343b3dbb74dd782d128e53a759453 |
| 출처 메모 | uspto-grants-2010_04 |