5-Hexynoic acid → 6-[3-(2-Hydroxy-1-methyl-ethylcarbamoyl)phenyl]-hex-5-ynoic acid

HRID 643042

반응식

HRID 643042 반응식
[OH:1][CH2:2][CH:3]([NH:5][C:6](=[O:14])[C:7]1[CH:12]=[CH:11][CH:10]=[C:9](I)[CH:8]=1)[CH3:4].[C:15]([OH:22])(=[O:21])[CH2:16][CH2:17][CH2:18][C:19]#[CH:20]>>[OH:1][CH2:2][CH:3]([NH:5][C:6]([C:7]1[CH:8]=[C:9]([C:20]#[C:19][CH2:18][CH2:17][CH2:16][C:15]([OH:22])=[O:21])[CH:10]=[CH:11][CH:12]=1)=[O:14])[CH3:4]

참가 물질

3

반응물 2

HCID 1430365-Hexynoic acidHCID 23730076N-(2-hydroxy-1-methyl-ethyl)-3-iodobenzamide

생성물 1

HCID 113582156-[3-(2-Hydroxy-1-methyl-ethylcarbamoyl)phenyl]-hex-5-ynoic acid수율 99%

실험 절차

The iodobenzamide (1)(2.00 g, 6.5 mmol) was coupled with 5-hexynoic acid using method B yielding (4)(1.87 g, 6.42 mmol; 99% yield).

출처 및 근거

ORD 기록
ord-65a9a2696d3042fda71f0ee0334b27e5
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696382B2

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