HCID 136928067, 화합물 → HCID 136928110, 화합물

HRID 64308노트

반응식

HRID 64308 반응식
C([N:8]1[CH2:13][CH2:12][C:11]2([N:17]3[N:18]=[C:19]([C:24]4[CH:29]=[CH:28][C:27]([O:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:26][CH:25]=4)[C:20]([C:21]([NH2:23])=[O:22])=[C:16]3[NH:15][CH2:14]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.CC(O)=O.[OH-].[OH-].[Pd+2]>[O:30]([C:27]1[CH:26]=[CH:25][C:24]([C:19]2[C:20]([C:21]([NH2:23])=[O:22])=[C:16]3[NH:15][CH2:14][C:11]4([CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[N:17]3[N:18]=2)=[CH:29][CH:28]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

참가 물질

5

반응물 1

HCID 136928067HCID 136928067, 화합물

생성물 1

HCID 136928110HCID 136928110, 화합물수율 51.4%

시약·촉매·용매 3

HCID 176Acetic Acid촉매HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

A mixture of 1′-benzyl-6-(4-phenoxyphenyl)-1,2-dihydrospiro[imidazo[1,2-b]pyrazole-3,4′-piperidine]-7-carboxamide (50 mg, 0.10 mmol), 10% w/w Pd(OH)2/C (5 mg) in MeOH (10 mL) and HOAc (1 drop) was stirred for 16 hr under H2. The mixture was filtrated and the filtrate was concentrated to give the crude product (20 mg 51.4%) as a yellow solid. MS (ESI, m/e) [M+1]+ 390.0.

후처리

  1. filtrationThe mixture was filtrated
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-2eeb7802e5a74bebb486d86771d06c3a
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447106B2

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