Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,2-Diethoxyethylamine → 2,2-Dimethoxy-n-[(1-methyl-1h-benzimidazol-2-yl)methyl]ethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,2-Diethoxyethylamine | HCID 69524 | — |
| 반응물 | 1-methyl-1H-1,3-benzodiazole-2-carbaldehyde | HCID 762084 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2,2-Dimethoxy-n-[(1-methyl-1h-benzimidazol-2-yl)methyl]ethanamine | HCID 55218525 | 77.1% |
반응 단계
A solution of 1-methyl-2-formylbenzimidazole (1 g) in methanol (27 mL) and acetic acid (0.54 mL) was treated with aminoacetaldehyde diethylacetal (0.9 g, 1 equivalent) and NaCNBH3 (0.85 g, 2 equivalents) at 25° C., stirred for 1 hour. The mixture was partitioned between water and ethyl acetate. The organic layer was separated, washed sequentially with saturated NaHCO3 and brine, and concentrated. The residue was purified by eluting with 8% methanol/dichloromethane to give 1.2 g (64%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07696226B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-ad9d204e608a4e9bbacd289dd9b366e6 |
| 출처 메모 | uspto-grants-2010_04 |