Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → methyl (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-[4-(6-hydroxy-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-4-oxo-butanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 6-Hydroxy-3-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one | HCID 21102207 | — |
| 반응물 | 1-methyl (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-succinate | HCID 86604295 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | methyl (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-[4-(6-hydroxy-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-4-oxo-butanoate | HCID 69071695 | — |
반응 단계
A solution of 1.37 g (4.04 mmol) 1-methyl (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-succinate, 1.42 g (4.40 mmol) TBTU, 0.63 mL (4.50 mmol) triethylamine and 1.00 g (4.04 mmol) 6-hydroxy-3-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one in 10 mL DMF was stirred for 3 h at RT. The reaction mixture was poured onto 300 mL saturated NaHCO3 solution, the precipitated substance was suction filtered, washed with 50 mL water and dried at 60° C. in the circulating air dryer.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07696209B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-42f657904f034372909ef82d7e496329 |
| 출처 메모 | uspto-grants-2010_04 |