2-Bromo-1-(3-nitrophenyl)ethan-1-one → HCID 178513496, 화합물

HRID 64315

반응식

HRID 64315 반응식
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:9][CH:8]=2)[C:3]=1[C:20]([NH2:22])=[O:21].Br[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([N+:33]([O-:35])=[O:34])[CH:28]=1)=O>CCO>[N+:33]([C:29]1[CH:28]=[C:27]([C:25]2[NH:1][C:2]3[N:6]([CH:24]=2)[N:5]=[C:4]([C:7]2[CH:8]=[CH:9][C:10]([O:13][C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)=[CH:11][CH:12]=2)[C:3]=3[C:20]([NH2:22])=[O:21])[CH:32]=[CH:31][CH:30]=1)([O-:35])=[O:34]

참가 물질

4

반응물 2

HCID 752132-Bromo-1-(3-nitrophenyl)ethan-1-oneHCID 178513497HCID 178513497, 화합물

생성물 1

HCID 178513496HCID 178513496, 화합물수율 11.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide (29.4 mg, 0.1 mmol) and 2-bromo-1-(3-nitrophenyl)ethanone (24.4 mg, 0.1 mmol) in EtOH (2 mL) was stirred at 80° C. for 16 hr. The mixture was filtered to afford 5 mg of crude 2-(3-nitrophenyl)-6-(4-phenoxyphenyl)-1H-imidazo[1,2-b]pyrazole-7-carboxamide as a yellow solid. MS (ESI) m/e [M+1]+ 440.0.

후처리

  1. filtrationThe mixture was filtered

출처 및 근거

ORD 기록
ord-ee2d4ce594704a0985377a363f5590cf
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447106B2

연결된 노트

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