Water → HCID 21555860, 화합물

HRID 643285노트

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HRID 643285 반응식
F[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13].O.[OH-].[NH4+:22]>>[NH2:22][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13]

참가 물질

4

반응물 3

HCID 962WaterHCID 14923Ammonium HydroxideHCID 27375522-Fluoro-3-(trifluoromethyl)benzophenone

생성물 1

HCID 21555860HCID 21555860, 화합물수율 90%

반응 조건

온도
140 °C

실험 절차

A suspension of (2-fluoro-3-trifluoromethyl-phenyl)-phenyl-methanone (0.5 g, 1.87 mmol) in 10 ml of ammonium hydroxide (28%) was sealed in a heavy-welled Pyrex tube. The sealed tube was heated at 140° C. overnight. The reaction was poured into water/saturated ammonium chloride solution and extracted with ethyl acetate. The combined organics was dried over MgSO4 and concentrated to give (2-amino-3-trifluoromethyl-phenyl)-phenyl-methanone as an oil (0.45 g, 90%). MS ESI (m/z) 266 ([M+H]+);

후처리

  1. customwas sealed in a heavy-welled Pyrex tube
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organics was dried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-613f98253c564c3ca993aff978fd0223
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700595B2

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