1-(5-Bromo-2-fluorophenyl)ethanol → 1-(5-Bromo-2-fluorophenyl)ethanone
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([CH:8]([OH:10])[CH3:9])[CH:7]=1>O1CCOCC1.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1참가 물질
4
실험 절차
To a solution of 1-(5-Bromo-2-fluoro-phenyl)-ethanol 102 (105 g, 0.479 mol) in dioxane (2 L) was added manganese dioxide (203 g, 2.35 mol). The reaction mixture was heated under reflux for 5 hours. The reaction mixture was allowed to cool to room temperature. The reaction mixture was filtered through Celite and the solid was washed with ether (1 L). The combined filtrate was evaporated under reduced pressure to afford the 1-(5-Bromo-2-fluoro-phenyl)-ethanone 103 (95.7 g, 0.441 mol) which was used in the next step without further purification.
후처리
- temperatureThe reaction mixture was heated
- temperatureunder reflux for 5 hours
- filtrationThe reaction mixture was filtered through Celite
- washthe solid was washed with ether (1 L)
- customThe combined filtrate was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-98b69f5c9b2f43afaa1eeb80b889744a
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07700601B2
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