2-Chlorobenzoyl chloride → 7-Bromo-3-(2-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine
반응식
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][NH2:9])[CH:3]=1.[Cl:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13](Cl)=O>CO>[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[C:13]([C:12]3[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=3[Cl:10])=[N:9][N:8]=[C:4]2[CH:3]=1참가 물질
4
반응 조건
- 온도
- 115 °C
실험 절차
A mixture of 1-(4-bromopyridin-2-yl)hydrazine (1.00 g, 5.3 mmol) and 2-chlorobenzoyl chloride (8.00 ml, 63 mmol, Aldrich) was heated to 115° C. for 3 h. The mixture was diluted with MeOH and concentrated over SiO2. The residue was purified using column chromatography (MeOH/CH2Cl2=0-10%) yielding the title compound as a tan solid. MS (ESI, pos. ion) m/z: 264.0 (M+1).
후처리
- concentrationconcentrated over SiO2
- customThe residue was purified
출처 및 근거
- ORD 기록
- ord-b13c72e7b41f4f72893123222bbaa41a
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07700593B2
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