Sodium Azide → HCID 86630625, 화합물
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[N-:1]=[N+:2]=[N-:3].[Na+].CS(O[CH2:10][C:11]([S:14]([C:17]1[CH:34]=[CH:33][C:20]2[N:21]([CH2:29][CH:30]3[CH2:32][CH2:31]3)[C:22]([CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[N:23][C:19]=2[CH:18]=1)(=[O:16])=[O:15])([CH3:13])[CH3:12])(=O)=O>CN(C=O)C>[N:1]([CH2:13][C:11]([S:14]([C:17]1[CH:34]=[CH:33][C:20]2[N:21]([CH2:29][CH:30]3[CH2:31][CH2:32]3)[C:22]([CH2:24][C:25]([CH3:26])([CH3:27])[CH3:28])=[N:23][C:19]=2[CH:18]=1)(=[O:16])=[O:15])([CH3:10])[CH3:12])=[N+:2]=[N-:3]참가 물질
4
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- 온도
- 160 °C
실험 절차
To a solution of sodium azide (176 mg, 2.70 mmol) in N,N′-dimethylformamide (5 mL) was added 2-{[1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-1H-benzimidazol-5-yl]sulfonyl}-2-methylpropyl methanesulfonate (Step I, 411 mg, 0.90 mmol) in N,N′-dimethylformamide (3 mL) at room temperature. The mixture was stirred at 160° C. for 24 h. The mixture was washed with ethyl acetate (20 mL×3) and water (30 mL). The combined organic layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=5:2 as eluent) to afford the title compound (265 mg) as a white amorphous.