Ammonium Hydroxide → Levobupivacaine

HRID 643763노트

반응식

HRID 643763 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C@H:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.C(C(C(C([O-])=O)O)O)([O-])=O.[OH-].[NH4+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C@H:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 86591002Levobupivacaine tartrate

생성물 1

HCID 92253Levobupivacaine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

45 g of levobupivacaine tartrate were dissolved in 222 mL of water under stirring. Concentrated ammonium hydroxide was added under stirring until the pH adjusted at 9-10. The solids were filtered and washed with 222 mL of water. The solids were dried in an oven with temperature around 45° C. until constant weight. Yield 27.6 g of enriched levobupivacaine free base (70%≦ee≦80%), MP=125-132° C.

후처리

  1. stirringunder stirring until the pH
  2. filtrationThe solids were filtered
  3. washwashed with 222 mL of water
  4. customThe solids were dried in an oven with temperature around 45° C. until constant weight

출처 및 근거

ORD 기록
ord-73b4d2ebe2184472a1829a8c3c010dc1
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700629B2

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