Acetic Acid → 2-(4-Aminophenoxy)-2-methylpropanoic acid

HRID 6440

반응식

HRID 6440 반응식
[NH:1]([C:5]1[CH:17]=[CH:16][C:8]([O:9][C:10]([CH3:15])([CH3:14])[C:11]([OH:13])=[O:12])=[CH:7][CH:6]=1)C(C)=O.C(O)(=O)C>[OH-].[K+]>[NH2:1][C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]([CH3:15])([CH3:14])[C:11]([OH:13])=[O:12])=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 148798552-(4-Acetamidophenoxy)-2-methylpropanoic acid

생성물 1

HCID 27749582-(4-Aminophenoxy)-2-methylpropanoic acid수율 62%

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

실험 절차

1.18 g (0.005 mol) of the 2-(4-acetaminophenoxy)-2-methyl propionic acid is boiled in 10% KOH (60 ml) for 1/2 hour. The solution is then cooled and acidified with acetic acid to yield 0.6 g (62% yield) of 2-(4-aminophenoxy)-2-methyl propionic acid as a yellowish white powder, mp 214°-16° C.

후처리

  1. temperatureThe solution is then cooled

출처 및 근거

ORD 기록
ord-13b9f603fcc84708924f96e5ef9dda01
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05248785

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