Water → HCID 59263302, 화합물

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참가 물질

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HCID 962Water

HCID 1140Toluene

HCID 6228Dimethylformamide

HCID 592633063-Fluoro-5-[4-(methanesulfonyl)phenoxy]benzonitrile

생성물 1

HCID 59263302HCID 59263302, 화합물

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온도: 70 °C

실험 절차

3-Fluoro-5-(4-methanesulfonyl-phenoxy)-benzonitrile (22.31 mmol; 6.50 g) was dissolved in dry DMF (32.5 ml) and this was added to the flask containing the anion of S-1-methoxyproapan-2-ol. The mixture was heated to 70° C. and held at 70° C. for 18 hrs. Water (20 ml) was added, then sufficient toluene to dissolve the precipitated solid was added. The mixture was extracted further with toluene (3×100 ml) and the combined toluene extract was washed with water (3×200 ml). The toluene layers were distilled down to low volume in vacuo and iso-hexane was added (50 ml). The resulting precipitate of the desired product was filtered off, washed with iso-hexane (2×25 ml) and dried in a vacuum oven at 40° C. overnight (6.0 g, 74.4% yield).