4-(3-Bromopropoxy)-2-fluorobenzonitrile → 4-(3-{4-[3-(4-Cyanophenoxy)propyl]-1-piperidinyl}propoxy)-2-fluorobenzonitrile

HRID 644123노트

반응식

HRID 644123 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.Br[CH2:20][CH2:21][CH2:22][O:23][C:24]1[CH:31]=[CH:30][C:27]([C:28]#[N:29])=[C:26]([F:32])[CH:25]=1>>[C:15]([C:14]1[CH:13]=[CH:12][C:11]([O:10][CH2:9][CH2:8][CH2:7][CH:4]2[CH2:5][CH2:6][N:1]([CH2:20][CH2:21][CH2:22][O:23][C:24]3[CH:31]=[CH:30][C:27]([C:28]#[N:29])=[C:26]([F:32])[CH:25]=3)[CH2:2][CH2:3]2)=[CH:18][CH:17]=1)#[N:16]

참가 물질

3

반응물 2

HCID 230339634-(3-Bromopropoxy)-2-fluorobenzonitrileHCID 592630194-[3-(4-Piperidinyl)propoxy]benzonitrile

생성물 1

HCID 686907234-(3-{4-[3-(4-Cyanophenoxy)propyl]-1-piperidinyl}propoxy)-2-fluorobenzonitrile수율 48.3%

실험 절차

As described in Reference Example 7, 0.12 g of 4-[3-(4-piperidinyl)propoxy]benzonitrile and 0.15 g of 4-(3-bromopropoxy)-2-fluorobenzonitrile were used to provide 0.10 g of 4-(3-{4-[3-(4-cyanophenoxy)propyl]-1-piperidinyl}propoxy)-2-fluorobenzonitrile as white solid form.

출처 및 근거

ORD 기록
ord-22039a8d1da44bc7bf675b4db9cfc052
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700623B2

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