Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 644172생성일: 2026년 10월 24일
Pyrrolidine → 2-[4-(pyrrolidin-1-yl)-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide
https://huagongshe.com/ko/reaction/644172
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 2-[4-Fluoro-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide | HCID 68530207 | — |
| 생성물 | 2-[4-(pyrrolidin-1-yl)-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide | HCID 68534238 | 90% |
반응 단계
Using methods substantially equivalent to those described in example 4-F except that the reaction was heated to 80° C., 2-[4-(pyrrolidin-1-yl)-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide (101 mg, 0.16 mmol, 90%) was prepared from 2-[4-fluoro-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-benzoylamino]-N-(5-chloropyridin-2-yl)benzamide and pyrrolidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07700628B2 |
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| 출처 데이터셋 | uspto-grants-2010_04 |
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| ORD ID | ord-3a8fb69afb4c4733887b763d95895037 |
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| 출처 메모 | uspto-grants-2010_04 |
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