1H,2H,2AH,3H,4H,8BH-Naphtho[1,2-B]azet-2-one → methyl rac-(1S,2S)-1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride

HRID 64419노트

반응식

HRID 64419 반응식
[NH:1]1[C:4](=[O:5])[CH:3]2[CH2:6][CH2:7][C:8]3[C:13]([CH:2]12)=[CH:12][CH:11]=[CH:10][CH:9]=3.[ClH:14].[CH3:15][OH:16]>>[ClH:14].[NH2:1][CH:2]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6][CH:3]1[C:4]([O:16][CH3:15])=[O:5]

참가 물질

3

반응물 2

HCID 3002861H,2H,2AH,3H,4H,8BH-Naphtho[1,2-B]azet-2-oneHCID 21893726Hydrochloride methanol

생성물 1

HCID 86713429methyl rac-(1S,2S)-1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride

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온도
90 °C

실험 절차

To 2.36 g of 2a,3,4,8b-tetrahydronaphtho[1,2-b]azet-2(1H)-one was added 50 ml of a 10% hydrogen chloride/methanol solution, followed by stirring at 90° C. for 6 hours. After leaving to be cooled, the solvent was evaporated under reduced pressure. To the obtained residue were added methanol and diethyl ether, and the insoluble material was collected by filtration and dried to obtain 3.08 g of methyl rac-(1S,2S)-1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride.

후처리

  1. customAfter leaving
  2. temperatureto be cooled
  3. customthe solvent was evaporated under reduced pressure
  4. additionTo the obtained residue were added methanol and diethyl ether
  5. filtrationthe insoluble material was collected by filtration
  6. customdried

출처 및 근거

ORD 기록
ord-8f1e3bd1cf164e369dba1efa3822e546
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447090B2

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