Methanol → methyl rac-(1R,2R)-1-aminoindane-2-carboxylate hydrochloride

HRID 64420노트

반응식

HRID 64420 반응식
C(OC([NH:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH:10]1[C:18]([OH:20])=[O:19])=O)(C)(C)C.S(Cl)([Cl:23])=O.[CH3:25]O>>[ClH:23].[NH2:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH:10]1[C:18]([O:20][CH3:25])=[O:19]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 207435011-[(tert-Butoxycarbonyl)amino]-2,3-dihydro-1H-indene-2-carboxylic acid

생성물 1

HCID 23002662methyl rac-(1R,2R)-1-aminoindane-2-carboxylate hydrochloride

실험 절차

To a suspension of 750 mg of rac-(1R,2R)-1-[(tert-butoxycarbonyl)amino]indane-2-carboxylic acid in 15 ml of methanol was added 0.40 ml of thionyl chloride, followed by stirring overnight. The solvent was evaporated to about a half amount thereof under reduced pressure, to the obtained residue was added diethyl ether, and the insoluble material was collected by filtration and dried to obtain 512 mg of methyl rac-(1R,2R)-1-aminoindane-2-carboxylate hydrochloride.

후처리

  1. customThe solvent was evaporated to about a half amount
  2. additionunder reduced pressure, to the obtained residue was added diethyl ether
  3. filtrationthe insoluble material was collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-460ce756d8c747909d62ad09cb7b4b3b
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447090B2

반응 노트

불러오는 중…