Methanol → Methyl 4-isopropyl-2-methoxymethoxybenzoate

HRID 644211노트

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HRID 644211 반응식
C(Cl)Cl.[CH:4]([C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([O:16][CH2:17][O:18][CH3:19])[CH:8]=1)([CH3:6])[CH3:5].CO.[CH3:22][Si](C=[N+]=[N-])(C)C>CC(O)=O.CCCCCC>[CH:4]([C:7]1[CH:15]=[CH:14][C:10]([C:11]([O:13][CH3:22])=[O:12])=[C:9]([O:16][CH2:17][O:18][CH3:19])[CH:8]=1)([CH3:6])[CH3:5]

참가 물질

7

반응물 4

HCID 887MethanolHCID 6344DichloromethaneHCID 167693TrimethylsilyldiazomethaneHCID 685322784-Isopropyl-2-methoxymethoxybenzoic acid

생성물 1

HCID 68533886Methyl 4-isopropyl-2-methoxymethoxybenzoate

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 8058Hexane용매

실험 절차

Into methylene chloride (40 mL) was dissolved 4-isopropyl-2-methoxymethoxy-benzoic acid (6.0 g, 26.8 mmol). Methanol (10 mL) was added, followed by the dropwise addition of 2 M hexane solution of trimethylsilyldiazomethane (14.7 mL). After 2 h, HOAc (0.5 mL) was added and the solvent was removed under vacuum, giving the title compound as an oil, which was used in next step without further purification.

후처리

  1. customthe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-d11ef92e482541bb958da1018f73d6b8
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700628B2

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