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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 644254생성일: 2026년 10월 25일

3-Nitropyridin-2-ylamine → 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)-benzoylamino]-N-(3-nitropyridin-2-yl)benzamide

https://huagongshe.com/reaction/644254

반응식

참여 물질

역할이름HCID투입량
반응물3-Nitropyridin-2-ylamineHCID 77887—
반응물6-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-oneHCID 57860842—
반응물5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(3-nitro-pyridin-2-yl)benzamide hydrochlorideHCID 68532907—
생성물5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)-benzoylamino]-N-(3-nitropyridin-2-yl)benzamideHCID 57860841—

반응 단계

Using methods substantially equivalent to those described in Example 118, 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(3-nitro-pyridin-2-yl)benzamide hydrochloride was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 2-amino-3-nitro-pyridine.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07700628B2
출처 데이터셋uspto-grants-2010_04
ORD IDord-7ec737d003a04eeca340e52d70ec6f32
출처 메모uspto-grants-2010_04