4-Azetidin-1-yl-1-benzyl-piperidine → 4-(Azetidin-1-YL)piperidine

HRID 644356노트

반응식

HRID 644356 반응식
[N:1]1([CH:5]2[CH2:10][CH2:9][N:8](CC3C=CC=CC=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[H][H]>CO.[Pd]>[N:1]1([CH:5]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 231533994-Azetidin-1-yl-1-benzyl-piperidineHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 231531094-(Azetidin-1-YL)piperidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

3.2 g (13.9 mmol) 4-azetidin-1-yl-1-benzyl-piperidine dissolved in 50 mL MeOH were hydrogenated in the autoclave in the presence of 0.5 g Pd/C (10%) at 50° C. and 3 bar hydrogen pressure until the calculated volume of hydrogen had been taken up. The catalyst was filtered off and the solvent was eliminated under reduced pressure.

후처리

  1. filtrationThe catalyst was filtered off

출처 및 근거

ORD 기록
ord-a920274d7d824753a91b7afa7bd1fc4f
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700589B2

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